Opioids and Depression
Pain and depression are closely linked. Living in pain can lead to depression, but depression is also linked to certain pain medications, including opioids. At LA Pain Doctor, we help patients in Metairie, LaPlace, Harvey, Hammond, and Lutcher, LA understand this connection and care for both their physical and emotional health.
Request an AppointmentHow Pain and Depression Are Connected
Chronic pain can make it hard to work, sleep, and enjoy time with others. Over time, this loss of normal life can lead to sadness, frustration, and hopelessness. Depression, in turn, can make pain feel more intense and harder to manage. This creates a cycle that can be difficult to break without addressing both sides.
How Opioids Can Affect Mood
Research has found that long-term opioid use is associated with a higher risk of depression. Opioids affect brain chemicals involved in mood and reward. Over time, the brain may become less able to feel pleasure on its own, and side effects such as fatigue, poor sleep, and low motivation can contribute to depressed feelings. Withdrawal between doses may also cause mood swings and anxiety. Learn more about side effects of long-term opioid use.
Signs of Depression to Watch For
- Feeling sad, empty, or hopeless most of the day
- Losing interest in activities you once enjoyed
- Changes in sleep or appetite
- Feeling tired or having little energy
- Trouble concentrating or making decisions
- Feelings of worthlessness or guilt
- Thoughts of death or suicide
If you have thoughts of harming yourself, call or text 988 to reach the Suicide and Crisis Lifeline, or call 911 right away.
Getting Help
Tell your provider if you notice changes in your mood. Depression is treatable, and addressing it can improve your pain as well. Your provider may adjust your medication, recommend a safe opioid taper, or refer you to a mental health professional. Exercise, sleep, and social support also help; see our guides on living with chronic pain and exercising with chronic pain.
Non-opioid treatments like lumbar epidural steroid injections, facet joint injections, and spinal cord stimulator implants may reduce your need for opioids. Visit our pain medication management page for more.
Opioids and Depression FAQs
Can opioids cause depression?
Long-term opioid use is associated with a higher risk of depression, partly due to effects on brain chemistry and sleep.
Does chronic pain cause depression?
Chronic pain often leads to depression, and depression can make pain feel worse.
What should I do if I feel depressed while taking opioids?
Tell your provider. They can adjust your treatment and connect you with mental health support.
Can tapering opioids help my mood?
Some patients notice improved mood after a safe, gradual taper, though changes take time.
Is depression treatable for people with chronic pain?
Yes. Counseling, medication, exercise, and better pain control can all help.
What if I have thoughts of suicide?
Call or text 988 for the Suicide and Crisis Lifeline, or call 911 right away.
How do I talk to LA Pain Doctor about this?
Call (504) 229-4866 - Metairie Office , (504) 229-4866 - Laplace Office , (504) 229-4866 - Harvey Office , (504) 229-4866 - Hammond Office or (504) 229-4866 - Lutcher Office to schedule a confidential visit with our team.
Care for Your Body and Mind
Let us help you find balanced, effective pain treatment. Call (504) 229-4866 - Metairie Office , (504) 229-4866 - Laplace Office , (504) 229-4866 - Harvey Office , (504) 229-4866 - Hammond Office or (504) 229-4866 - Lutcher Office or request an appointment online today.